Fig. 4.
Fig. 4. Overexpression of Gln78Leu but not of Trp73Gly Rab27a mutants interferes with melanosome transport, a phenotype rescued by SHD-Mlph overexpression. / Melan-a cells were transfected with plasmids encoding pEGFP-C1 allowing soluble GFP expression (A), or cotransfected with pEGFP-C1 and pcDNA3 encoding Trp73Gly (C), Gln78Leu (E), SHD-Mlph (G), or Gln78Leu and SHD-Mlph (I) proteins. Panels B, D, F, H, and J are images of transmitted light showing the distribution of melanosomes. Bars indicate 20 μm.

Overexpression of Gln78Leu but not of Trp73Gly Rab27a mutants interferes with melanosome transport, a phenotype rescued by SHD-Mlph overexpression.

Melan-a cells were transfected with plasmids encoding pEGFP-C1 allowing soluble GFP expression (A), or cotransfected with pEGFP-C1 and pcDNA3 encoding Trp73Gly (C), Gln78Leu (E), SHD-Mlph (G), or Gln78Leu and SHD-Mlph (I) proteins. Panels B, D, F, H, and J are images of transmitted light showing the distribution of melanosomes. Bars indicate 20 μm.

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