Hb analysis in TNS9-rescued mice.

Cellulose acetate electrophoresis of peripheral blood lysates was performed monthly. Hb levels (g/dL) are indicated at the bottom of each lane. Hb^mu indicates mouse Hb tetramer; Hb^hu, Hb tetramer composed of mouse α and human β chains; WT, wild-type mouse, showing Hb single; and TG, transgenic mouse blood,9,10 15 showing hemoglobin tetramers that incorporate human β^A (Hbb^hu, 14% of total Hb). TNS9: 4 TNS9-transduced Hbb^th3/th3 FLCs mice (3 on one gel on the left and one on another gel to the right) 8 weeks (A) and 4 months (B) after transplantation.