Ribbon diagram of the αV subunit showing the relative locations of the αIIb mutations of patients M and C.

The αIIb and αV subunits share 40% sequence homology. This ribbon diagram of αV shows the relative positions of the 4 αIIb mutations, which are indicated by spheres (missense mutation) or a block (nonsense mutation) centered on the amino acid α-carbons (red and underlined for patient M, black for patient C). The β-propeller blades are designated W1-W7; the calcium atoms are shown in yellow. Three mutations lie within the β-propeller domain, blades W5 and W6, and the fourth is within the calf-1 domain. This image was generated with MOLMOL36 from the PDB file 1JV2.13