Fig. 9.
Cell cycle analysis on effects of inhibitors.
Cell cycle analysis performed on mutant N-ras– or K-ras–containing cells following treatment for 48 hours without or with FTI-277 at 20 μM, rapamycin (RAP) at 1 μM or anti-fas at 0.1 μg/mL. Analysis was also performed on N-ras cells following infection with control Ad-CMV or IKB-sr adenovirus at MOI = 100. Data represent the percentage of cells in S phase (■) or sub-G1 fraction (▧), means ± SDs for 3 separate experiments.