Tg A1-a does not protect against reactivation-induced AICD.

Following primary activation with Con A and IL-2, splenocytes were cultured in the presence of IL-2 either on control or αCD3-coated plates. Apoptosis was measured as percent hypodiploid nuclei. Values represent the mean ± SE for 3 mice. At 1 day after reactivation the mean percentage of T cells in the cultures (measured as the percentage of PI-excluding cells expressing either CD4 or CD8) was 86% (range, 83%-89%). The data are representative of 3 similar experiments.