Fig. 8.
Effect of EB1089 on MAP kinase activity in B-CLL cells.
Cells were incubated for 12 hours with 1 × 10−8 M EB1089 and were then stained with FITC-labeled phosphorylation-specific antibodies. (A) The p38 MAP kinase was phosphorylated following exposure to EB1089 (open histogram) when compared with the no-drug controls (shaded histogram). (B) In contrast, phosphorylation of ERK was inhibited by EB1089 (open histogram) when compared with the no-drug controls (shaded histogram).
