Changes in renal levels of 6-keto-PGF_1α in rats subjected to renal ischemia/reperfusion and effects of antithrombin (AT) and other materials on renal ischemia/reperfusion–induced increases in renal levels of 6-keto-PGF_1α.

(A) Renal levels of 6-keto-PGF_1α were determined just before ischemia (Pre) and at indicated time points after reperfusion. (B) Renal levels of 6-keto-PGF_1α were determined 1 hour after reperfusion in rats subjected to renal ischemia/reperfusion (I/R). mAT indicates Trp49-modified AT. Data are expressed as means ± SDs from 6 animals. *P < .01 versus sham-operated group; †P < .05 versus vehicle-treated group; §P < .01 versus AT-treated group.