Effects of antithrombin (AT) and other materials on renal ischemia/reperfusion (I/R)–induced increases in renal levels of tumor necrosis factor-α (TNF-α), cytokine-induced neutrophil chemoattractant (CINC), and myeloperoxidase (MPO) activity.

Renal levels of TNF-α and CINC were determined 3 hours after reperfusion and renal levels of MPO activity were determined at 6 hours after reperfusion. mAT indicates Trp49-modified AT. Data are expressed as mean ± SD values of 6 animals. *P < .01 versus sham-operated group; †P < .01 versus vehicle-treated group; §P < .01 versus AT-treated group; ¶P < .01 versus IM-treated group.