Shape of unsheared and sheared VWF.

SLS data from Figure 7A were used to determine the shape of VWF by plotting the shape factor (P_q) against the magnification factor (qR_g). Experimental points under the various conditions are depicted as discrete points, and theoretical predictions of P_qversusqR_g for spheres, rods, and polydispersed coils are presented as smooth lines (see online supplemental document for details). The unsheared sample appears rodlike, and the sheared sample resembles a polydispersed coil. The inset offers a closer look atqR_g values from 0 to 3.