Relapsed

MYC-induced tumors are independent ofMYC expression. Western blot analysis showed the protein levels of human c-MYC and mouse endogenous c-Myc, N-Myc, and L-Myc in primary and relapsed MYC-induced tumors. Anti-MYC 9E10 antibody detects only the human c-MYC transgene. Anti-Myc c19 antibody detects the human c-MYC transgene and endogenous murine c-Myc. Anti-N-Myc OP13 and anti-L-Myc c20 antibodies detect only N-Myc and L-Myc, respectively. Results from 3 primary tumors are shown in the left panel, and results from the relapsed tumors are shown in the right panel.