Different chromosomal abnormalities in primary versus relapsed

MYC-induced tumors. (A-D) SKY showing the complete karyotypes and chromosomal abnormalities in 2 primary and corresponding relapsed tumors. (A) Primary tumor 967 has trisomy 15 and 2 Y. (B) Relapsed tumor 967 R2 contains trisomy 4 and 8, HSRs on Chr 8 and 15, and nonreciprocal translocation t(3;4). Note that most of the metaphases from 967 R2 exhibited a loss of chromosome 8. (C) Primary tumor 6816 displays HSRs on Chr 15 and Y. (D) Relapsed tumor 6816 R3 exhibits trisomy 3, 11p+ and 15, and nonreciprocal translocation t(3;17).