Fig. 1.
Effect of promoter on human apo A-I expression and anti-human apo A-I antibodies after adenoviral gene transfer.
(A) Human apo A-I expression after adenoviral gene transfer with 5 × 108pfu AdAT4 (▿), AdC4 (▴), AdU(●), and AdCMV (♦) in Balb/c mice. Human apo A-I levels were below detection limit after transfer with any dose ofAdEβ (not shown). (B) Inverse of the titer of antibodies against human apo A-I after transfer with 5 × 108 pfuAdAT4 (▿), AdC4 (▴), AdU (●),AdCMV (♦), and AdEβ (▪) and after transfer with 108 pfu AdEβ (■) in Balb/c mice.
