Fig. 3.
![Fig. 3. The effect of the Src-family kinase inhibitor PP1 on IRBC cytoadherence in a human microvasculature in vivo. / The effects are shown on rolling IRBCs (A) and adhesion IRBCs (B) in a human microvasculature in vivo. Skin-grafted SCID mice were treated with PP1 or PP3 (1.5 mg/kg, 1 hour, ip [intraperitoneall]), and the skin graft was exposed for direct visualization of the adhesive interactions in human microvessels by means of intravital microscopy. Baseline data were obtained from untreated animals. The data are from 6 vessels in 2 untreated mice, 21 vessels in 2 mice treated with PP1, and 6 vessels in 1 mouse treated with PP3. Values are presented as means ± SEM. ***P < .001.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/101/7/10.1182_blood-2002-09-2841/3/h80734098003.jpeg?Expires=1735835103&Signature=w63S0Ibf9R20fYKNLWIv04DyqiVWNFlTSX4yzcTEApbGwYJNciL1nCckTViShba3rNppSDF7yzEGfFtJLNGXmvirZLzd4ExasBq7Q8UIufYlNFeieMevFbH1iMltP8tNs-7L1UeqZ31zoVhRaUou-H0vNBdUpwV6HWEef0f9oy6MG1CCTvCdVIicUcZK6MA1zc6CsFOEkW5Ll19oC0ndLjIWu0mwT3EW5a0a89ApxH3dvoZ0Jm15-FU1ZZBnDRi8xvupIGEO-G7KDV3FKfYd78gH~oajPXHHyi-euS6GIyWYDGnWH664MSG~lInOqp5C67rgZIMKjS616Wzgqisj6Q__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
The effect of the Src-family kinase inhibitor PP1 on IRBC cytoadherence in a human microvasculature in vivo.
The effects are shown on rolling IRBCs (A) and adhesion IRBCs (B) in a human microvasculature in vivo. Skin-grafted SCID mice were treated with PP1 or PP3 (1.5 mg/kg, 1 hour, ip [intraperitoneall]), and the skin graft was exposed for direct visualization of the adhesive interactions in human microvessels by means of intravital microscopy. Baseline data were obtained from untreated animals. The data are from 6 vessels in 2 untreated mice, 21 vessels in 2 mice treated with PP1, and 6 vessels in 1 mouse treated with PP3. Values are presented as means ± SEM. ***P < .001.
