Schematic representation of the experimental design.

Diagram shows the bleeding times (arrows) and blood samples (*) relative to the 50- to 60-minute infusion of plasmin or TPA. Infusions into rabbits (4 kg body weight) were performed in a randomized, blinded manner, using coded vials containing plasmin (16, 24, or 32 mg) or TPA (1, 2, or 4 mg) in a total volume of 10 mL. Data were pooled by group for statistical analysis, without knowledge of treatment. Control infusions of 10 mL saline to 5 animals were performed in an open-label manner at the end of the study.