Schematic representation of bleeding.

Bleeding is diagramed before, during, and after infusion of plasmin (left) or TPA (right) to groups of 5 rabbits. PBTs were performed on cohorts of 5 animals at −30 minutes, −10 minutes, and 0 minutes before infusion and at 10, 30, 60, 70, 90, 120, and 180 minutes after the start of infusion. The vertical shaded rectangle represents the infusion period from 0 to 55 to 60 minutes. The heavy lines indicate when bleeding occurred, either the primary bleeding times shown at the extreme left margin of each line, or renewed bleeding at these same sites over the 180-minute observation period. Intervals of stable hemostasis are indicated by the light horizontal lines.