Comparison of the amino acid sequence of Felic and CIP4.

Primary amino acid sequence of Felic is aligned with CIP4. The proline-rich motif, which provides a putative SH3 docking site, is shaded. Potential tyrosine phosphorylation sites are featured by boldface type. The Fes/CIP4 domain, also known as the RAEYL motif or the S pombe Cdc15 N-terminal domain, occurs at positions 1 to 56. The region with 30% homology to ezrin/radixin/moesin motif is found at positions 329 to 410. The Cdc42-binding region occurs at positions 338 to 467. CIP4 contains an SH3 domain at its C-terminus at positions 489 to 545.