Activated FLT3 cooperates with a

MRP8 PML-RARA transgene to cause leukemia.Survival curves are shown of mice reconstituted withPML-RARA transgenic or control FVB/N bone marrow after transduction with activated FLT3 (FLT3^W51) or control (FLT3^wt or GFP only) retroviruses. Overall survival, including leukemic and nonleukemic deaths, is shown (see “Results”). FLT3^W51/PR indicates activated FLT3 retrovirus in PML-RARA transgenic bone marrow (n = 15); FLT3^W51/control, activated FLT3 retrovirus in FVB/N bone marrow (n = 12); control/PR, control retroviral vector inPML-RARA transgenic bone marrow (n = 8); control/control, control retroviral vector in FVB/N bone marrow (n = 10).