ATRA causes immunophenotypic differentiation of leukemic cells.

Representative flow cytometry of splenic cells harvested from mice treated as described in the legend to Figure 6. Histograms are gated on R1. Dot plots are gated on R1 and R2 and, therefore, represent the GFP-positive leukemic cells. ATRA causes a loss of the immature marker CD117 (c-kit) and increased expression of the mature myeloid markers CD11b (Mac-1) and Ly-6G (Gr-1).