American Society of Hematology

Fig. 4.

$Fig. 4. The addition of a combination of compatible immunosuppressive drugs (rapa + MP + MMF) allows a further reduction of the minimal required dose of TBI. / To evaluate whether immunosuppressive drugs could partially replace TBI in this model, groups of mice were irradiated with different doses of TBI and some were additionally treated with a combination of immunosuppressive drugs. Mice received only TBI at doses of 1 Gy (A), 1.5 Gy (B), 2 Gy (C), or 3 Gy (D; standard-protocol group) or received a combination of rapa, MP, and MMF for 4 weeks in addition to TBI with 1 Gy (E), 1.5 Gy (F), 2 Gy (G), or 3 Gy (H). Fractions shown in each panel indicate the fraction of analyzed mice showing chimerism at the time point indicated below. In graphs, ⋄ indicates CD4 cells, ▪ indicates CD8 cells, ▴ indicates B cells, and ■ indicates monocytes/granulocytes.$

The addition of a combination of compatible immunosuppressive drugs (rapa + MP + MMF) allows a further reduction of the minimal required dose of TBI.

To evaluate whether immunosuppressive drugs could partially replace TBI in this model, groups of mice were irradiated with different doses of TBI and some were additionally treated with a combination of immunosuppressive drugs. Mice received only TBI at doses of 1 Gy (A), 1.5 Gy (B), 2 Gy (C), or 3 Gy (D; standard-protocol group) or received a combination of rapa, MP, and MMF for 4 weeks in addition to TBI with 1 Gy (E), 1.5 Gy (F), 2 Gy (G), or 3 Gy (H). Fractions shown in each panel indicate the fraction of analyzed mice showing chimerism at the time point indicated below. In graphs, ⋄ indicates CD4 cells, ▪ indicates CD8 cells, ▴ indicates B cells, and ■ indicates monocytes/granulocytes.

This Feature Is Available To Subscribers Only