The addition of immunosuppressive drugs (rapa + MP + MMF) improves donor skin-graft survival in mice receiving reduced doses of TBI.

All mice were injected with BM and cobl and irradiated with 1, 1.5, 2, or 3 (standard protocol) Gy. Some received a combination of rapa, MP, and MMF for 4 weeks after BMT and some received no further treatment in the same experiment. Third-party skin grafts (●) were promptly rejected in all groups. Results are shown for 1 and 1.5 Gy (A) and 2 and 3 Gy (B) with and without the immunosuppressive (IS) combination.