Studies of patient T-cell receptor (TcR) Vβ repertoire.

Percentage of T cells in each TcR Vβ family at various times during the study. The top panel shows patient 1 at protocol days 1795 (black bars), 2295 (white bars), 2733 (orange bars), 3063 (yellow bars), and 3559 (green bars). The second panel shows patient 1's cells divided into CD4 and CD8 cells on protocol day 2973; TcR Vβ14 was found predominantly in the CD8⁺ T-cell subset. The third panel shows patient 2's T cells tested on protocol days 2049 (black boxes), 2070 (white bars), 2718 (orange lined bars), and 3149 (yellow lined bars). No single TcR Vβ family was predominant at any of these time points. The bottom panel shows T cells from healthy control subjects showing range of TcR Vβ families detectable by FACS. Normal 1 (orange dotted bars), Normal 2 (green dotted bars), Immunotech normal low (white bars), and Immunotech normal high (black bars).