Fig. 1.
Fig. 1. IL-17 promotes in vivo tumor growth in a nonirradiation-dependent fashion. / (A) Recombinant IL-17 protein or transduction of the IL-17gene has no direct effect on in vitro growth of tumor cells determined by MTT assay. Each value represents mean ± SD (n = 5). (B-C) Mice were inoculated with MCA205WT, MCA205Neo, or MCA205IL-17 or with MC38WT, MC38Neo, or MC38IL-17. Each value represents mean tumor volume (cubic millimeter) ± SD for 6 or 7 mice per group. The result is a representative of 3 independent experiments. (D) Mice were irradiated with 500 rad whole-body irradiation before inoculation with MCA205Neo or MCA205IL-17. Each value represents mean tumor volume (cubic millimeter) ± SD for 5 mice per group. The result is a representative of 2 independent experiments.

IL-17 promotes in vivo tumor growth in a nonirradiation-dependent fashion.

(A) Recombinant IL-17 protein or transduction of the IL-17gene has no direct effect on in vitro growth of tumor cells determined by MTT assay. Each value represents mean ± SD (n = 5). (B-C) Mice were inoculated with MCA205WT, MCA205Neo, or MCA205IL-17 or with MC38WT, MC38Neo, or MC38IL-17. Each value represents mean tumor volume (cubic millimeter) ± SD for 6 or 7 mice per group. The result is a representative of 3 independent experiments. (D) Mice were irradiated with 500 rad whole-body irradiation before inoculation with MCA205Neo or MCA205IL-17. Each value represents mean tumor volume (cubic millimeter) ± SD for 5 mice per group. The result is a representative of 2 independent experiments.

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