Dose-dependent migration of HMVECs following stimulation with IL-17.

(A) HMVECs were allowed to grow over 5 days in the presence of increasing concentrations of IL-17. Bars represent mean cell number ± SD (n = 3). The result is a representative of 2 independent experiments (10 ng/mL bFGF versus 0-1000 ng/mL IL-17; *P < .05). (B) A wide range of doses of IL-17 stimulated the migration of HMVECs. BFGF (15 ng/mL) also stimulated the migration of HMVECs. Bars represent the mean number of migrated cells ± SD per 5 HPFs (× 200) (n = 5). The result is a representative of 3 independent experiments (control versus 0.05-100 ng/mL IL-17; *P < .05; 10 ng/mL IL-17 versus 10 ng/mL IL-17 + anti-IL-17 mAb; **P < .001).