Fig. 4.
Specificity of T-cell anergy to platelet Ags induced by CTLA4-Ig and/or CsA.
Following the same procedure for first culture as that described in Figure 2, the T cells rendered tolerant to platelet Ags were rechallenged with the original (■) or unrelated Ags (tuberculin, 20 U/mL; ▪) in the secondary culture in 12 patients. After 4 days, proliferative response was measured by [3H]thymidine incorporation and shown as mean ± SD cpm.