Model of the annexin A2–S100A10 (p11) heterotetramer, depicting binding of tPA and plasminogen (p19) leading to generation of plasmin (PLM). The anti–annexin A2 antibody (Antibody) might inhibit binding of tPA or PLG or block their interaction with each other. Illustration by A. Y. Chen; adapted from Figure 2B of Cesarman-Maus and Hajjar.⁵