Effect of anti–ICAM-2 mAb (3C4) and anti–ICAM-1 mAb (YN-1) on leukocyte responses in IL-1β–stimulated murine cremasteric venules as observed by intravital microscopy. Animals were treated with saline or IL-1β (50 ng per animal) intrascrotally 4 hours before the surgical preparation. In additional groups of mice, animals were pretreated with intravenous mAbs 3C4 or YN-1 or an isotype-matched control mAb, all at the dose of 3 mg/kg, 15 minutes before the intrascrotal injection of IL-1β. The data represent mean ± SEM from 2 to 8 mice per group. *P < .05 and **P < .01 versus responses obtained from saline-injected animals. Additional statistical comparisons are indicated by lines.