Figure 4.
![Figure 4. Activity of hepcidin derivatives in vivo. Diluent or peptides (50 μg/mouse) were injected in mice, and serum iron levels were determined after 2 hours. P values (Student t test) above bars denote statistically significant difference in comparison to PBS-injected mice. 25 = hep25; 20 = hep20 [del1-5(DTHFP)]; dKT = del24-25(KT); AA1 = C7A/C13A; AA3 = C11A/C19A; AA4 = C13A/C14A; 1SS = [del9-12(FCCG), del19-22(CGMC), C13A/C14A]. The activity corresponding to the naturally occurring active form of hepcidin is shown as a black bar. PBS and hep25 were each tested in 10 mice, and 4 to 6 mice were used for each of the other peptides.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/107/1/10.1182_blood-2005-05-2049/4/zh80010688580004.jpeg?Expires=1735525799&Signature=5J1eXZT7I3r-pAaumU-jcILnMBAbrb8HYnaxFE6r83roNxwkqBM-MDo~nkqsiFKMCADY4oraaWC~5ks1MLcWfbHz0Gsc-K75SfIO3ZzUu6FyAtfMZE~6zgJelHHzCisxG~xfwMAEnHcaVpy8hDJtvj5aV0LokCx6CYyV-wMHl2wM3MdNsTN8Hg4Evm~XqNagd9Iah~vCQqguu02R9Kin9rjRZ4C7IpvJemUv8kTL8ZKqV1GDNRBHOvxObGcgqzizWUTIV6~a1GnQgrS~lsOvg3O7TbKCVcXCgX2eoTW9DaD181MNK2~gX-xHKrH~YfXHg35cnCQXiE~e-mtD7wcHGQ__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Activity of hepcidin derivatives in vivo. Diluent or peptides (50 μg/mouse) were injected in mice, and serum iron levels were determined after 2 hours. P values (Student t test) above bars denote statistically significant difference in comparison to PBS-injected mice. 25 = hep25; 20 = hep20 [del1-5(DTHFP)]; dKT = del24-25(KT); AA1 = C7A/C13A; AA3 = C11A/C19A; AA4 = C13A/C14A; 1SS = [del9-12(FCCG), del19-22(CGMC), C13A/C14A]. The activity corresponding to the naturally occurring active form of hepcidin is shown as a black bar. PBS and hep25 were each tested in 10 mice, and 4 to 6 mice were used for each of the other peptides.
