Figure 2.
Asparagine synthetase (AS) mRNA expression induced by pegylated l-asparaginase (PEG-Asp) in time. Time-response curves of AS mRNA expression in the leukemic cells of 31 children after a single dose of PEG-Asp (1000 IU/m2 given intravenously at day –5). *A 3-fold increase in AS mRNA from day –5 to day –4 (P < .001).
