Figure 2.
Figure 2. Modest deficit in peripheral B cells of CBPflox/flox;CD19+/Cre and p300flox/flox;CD19+/Cre mice. The number of B cells and T cells per mL of peripheral blood for CBPflox/flox;CD19+/Cre (A) and p300flox/flox;CD19+/Cre (B) mice and controls. Number of mice of each genotype is indicated. Mean ± SEM. (C) Representative flow cytometric analysis using anti-IgM and anti-IgD antibodies and splenic lymphocytes from CD19+/Cre, CBPflox/flox;CD19+/Cre, and p300flox/flox;CD19+/Cre mice. Percentage of total splenic lymphocytes representing the major B-cell subtypes (IgMhi IgDlo, IgMhi IgDhi, IgMlo IgDhi). (D-E) Quantification of IgM and IgD flow cytometry data as in panel C for the indicated number of mice of each genotype (mean ± SEM). Flow cytometric analysis and complete blood count analyses for the CBPflox and p300flox groups were performed at different times and may not be directly comparable to each other.

Modest deficit in peripheral B cells of CBPflox/flox;CD19+/Cre and p300flox/flox;CD19+/Cre mice. The number of B cells and T cells per mL of peripheral blood for CBPflox/flox;CD19+/Cre (A) and p300flox/flox;CD19+/Cre (B) mice and controls. Number of mice of each genotype is indicated. Mean ± SEM. (C) Representative flow cytometric analysis using anti-IgM and anti-IgD antibodies and splenic lymphocytes from CD19+/Cre, CBPflox/flox;CD19+/Cre, and p300flox/flox;CD19+/Cre mice. Percentage of total splenic lymphocytes representing the major B-cell subtypes (IgMhi IgDlo, IgMhi IgDhi, IgMlo IgDhi). (D-E) Quantification of IgM and IgD flow cytometry data as in panel C for the indicated number of mice of each genotype (mean ± SEM). Flow cytometric analysis and complete blood count analyses for the CBPflox and p300flox groups were performed at different times and may not be directly comparable to each other.

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