NIP-004–induced production of human platelets in NOG mice receiving xenotransplants. (A) NIP-004 increased the number of circulating human platelets in NOG mice. (B) NIP-004 did not change the number of murine platelets or chimerism of HuCD45⁺ cells. NIP-004 had no effect on the percentage of human B (CD19⁺) cells, human T (CD3⁺) cells, and human myeloid (CD33⁺) cells in the peripheral HuCD45⁺ cells. Data from panels A-B are expressed as the mean ± SEM (n = 3). (C) NIP-004 increased the number of circulating human platelets. The increase was calculated as the number of circulating human platelets at individual time points divided by the pretreatment value (day 0). Data are expressed as the mean ± SEM (n = 3 to 6) or mean ± SD (n = 2). *P < .05, **P < .01 between NIP-004 and vehicle at individual time points. N.S. indicates no significant differences compared with vehicle.