Cumulative incidence and hazard rates of MDS/AML and death from sepsis in patients with SCN. Results are shown for patients in SCN Group 1 (Table 1). One additional death from sepsis at year 12.4 is not shown on the plot. (A) Cumulative incidence (cumulative proportion experiencing each event as initial cause of failure in subjects at risk of each adverse event), by years on therapy with G-CSF, and 95% CIs at selected years (error bars). Observed cumulative incidence (stair-step curves), and smoothed cumulative incidence (dashed curves) derived from estimated cause-specific hazard functions are shown. (B) Annual hazard rates (incidence rate per year among subjects who are still susceptible) of MDS/AML and death from sepsis, by years on G-CSF therapy, and 95% point-wise confidence envelopes (shaded regions).