Impaired T-cell activation in panPKC LMWI–treated cells. (A) Proliferative response and (B) IL-2 production of purified naive CD3⁺ T cells in the presence of the panPKC LMWI inhibitor, which reduces the proliferation (P = .016) and IL-2 secretion (P = .003) significantly. Cells were left unstimulated or were stimulated with anti-CD3 (precoated at a concentration of 10 μg mL^–1) plus soluble anti-CD28 (1 μg mL^–1), as indicated, and analysis was done by using standard procedures. Results shown are the mean ± SD of at least 3 independent experiments.