Representative examples of lymphoma subtypes immunostained for T-cell-associated transmembrane adaptor proteins LAT, LIME, and TRIM and the B-cell-associated molecule NTAL. Note cases of T-lymphoblastic lymphoma expressing these markers and cases of ALK⁺ anaplastic large-cell lymphoma (ALCL) that are negative for LIME and TRIM. The reactivity of cases of myeloma for LIME and TRIM is also shown. In contrast, LAT is not expressed in this tumor (note positive megakaryocyte). NTAL is expressed in B-cell lymphomas, and examples are also shown of 2 NTAL⁺ T-cell neoplasms (lymphoblastic and ALK⁺). In Hodgkin disease, NTAL expression is shown in a case of lymphocyte-predominant Hodgkin disease (LPHD) and in the classic subtype (arrows indicate lymphocytic and histiocytic cells and Reed-Sternberg cells). Image acquisition was performed as described for Figure 1.