TBI causes intrinsic damage to HSCs to inhibit long-term BM engraftment in a CRA. (A) Hematopoietic engraftment at 1 and 2 months after stem cell transplantation. The percentage of donor-derived peripheral-blood leukocytes from mice receiving a transplantation of irradiated or control LKS⁺ cells is expressed as mean ± SE (10 mice/group). (B) Multilineage reconstitution of myeloid (GM-granulocyte- monocyte/macrophage), T, and B cells was analyzed at 2 months after stem cell transplantation. The data are presented as mean ± SE (10 mice/group). ^***P < .001; ^**P < .01.