Cox-2 does not regulate IL-6–independent growth of mutant RAS–containing MM cells. Cells were cultured in full growth media (without IL-6) with DMSO, 10 μM NS398, or 15 μM celecoxib. Live cells were quantified by trypan blue exclusion, and the results are presented as number of viable cells (× 10⁵) for mutant N-RAS (A) and mutant K-RAS cells (B). This experiment was performed twice (n = 2) with each sample group in duplicate, and these data are representative of both experiments. Error bars indicate standard deviation of duplicate experiments.