Figure 5.
Microarray analysis of gene expression changes associated with TEL2 expression in mouse bone marrow. RNA from mouse bone marrow cells, either mock transduced (uninfected) or transduced with MSCV-TEL2-IRES-GFP (TEL2) or MSCV-IRES-GFP (GFP), were analyzed using the MOE-430A Affymetrix GeneChip microarrays. Log2 ratio values from pairwise comparisons are plotted. (A) Relative expression of 195 probe sets identified as differentially expressed (see “Materials and methods”) in both TEL2 versus GFP (x-axis) and TEL2 versus uninfected (y-axis) bone marrow. (B) Relative expression of differentially expressed probe sets found enriched (P < .001) in the Gene Ontology categories of apoptosis (left) or differentiation (right). Gene symbols are indicated in the panels.