Figure 7.
Angiogenic effects of purified chMMP-9. Control and HT-1080 cell–containing onplants were supplemented with either buffer or 100 ng purified chMMP-9 and placed on the CAM of nontreated embryos or embryos treated with ibuprofen. At 72 hours, angiogenesis was scored in the onplants to determine fraction of grids containing newly formed blood vessels. *P = .009; **P = .001.