Figure 2.
Apoptosis genes associated with resistance to four individual chemotherapeutic agents in B-lineage ALL. The global test and Wilcoxon rank-sum test were performed to identify which of the indicated 118 apoptosis probe sets were differentially expressed in B-lineage ALL cells sensitive and resistant to prednisolone (PRED), vincristine (VCR), L-asparaginase (ASP), and daunorubicin (DNR). For each drug, probe sets selected only by the global test (P <.001) are light gray, probe sets selected by the global test (P < .001) and Wilcoxon rank-sum test with FDR < 5% are black, and probe sets not selected by none of the tests are white. The numbers indicated in colored boxes are the ratio per significant gene between PRED-resistant and PRED-sensitive ALL samples (PRED), VCR-resistant and VCR-sensitive ALL samples (VCR), ASP-resistant and ASP-sensitive ALL samples (ASP), and DNR-resistant and DNR-sensitive ALL samples (DNR).