Figure 2.
Translocation junction analysis. (A) Distribution of deletion lengths in 172 translocation junctions formed by NHEJ for der(17) and der(14) junctions. Junctions are derived from neo+ clones from the 3 reporter cell lines. The der(14) junctions that are not shown here were repaired by SSA. NA indicates not applicable. (B) Scatter plot of translocation deletion lengths in which both derivative chromosome junctions in a neo+ clone arose by NHEJ. No correlation was noted between deletion lengths on der(17) and der(14) (r = -0.085). (C) Distribution of microhomologies in 138 translocation junctions. Only der(17) and der(14) junctions that were repaired by NHEJ without an insertion (ie, simple deletions) are included.