Mapping of the Lupo mutation. (A) Genomic structure of the mapping region on chromosome 18. Locations of flanking and cosegregating markers are indicated above the chromosomal ruler and the genes below it. Positions of genes Ccdc5, Atp5a1, Slc14a1, Slc14a2, Setbp1, and Pstpip2/Mayp and the mapped EST clones 8030462N17Rik and AK028969/AK122536 are shown. (B) Haplotypes of the informative mice (IC1 and IC2) define the mapping region.