The left panel shows inflammation observed in the homozygous mutant (Mayp^Lp/Lp) mouse, leading to osteolysis and localized necrosis of the digits. The right panel shows extensive infiltrates of F4/80-positive macrophages observed in thickened dermis in ear tissue in the homozygous mutant (Mayp^Lp/Lp) mouse. See the complete figure in the article beginning on page 3350.