The cellular barrier formed by ELMCs is responsive to bradykinin and histamine. A decrease in TCER is seen with the application of histamine (A) or bradykinin (B) to endothelial-like monocytic cells cultured on Transwells (bradykinin or histamine, •; vehicle, □). Experiments were done 3 times each; n = 3. TCER values for samples after the application of bradykinin or histamine were significantly lower than the controls at each time point (P < .05). Data are expressed as mean ± SEM.