Cytologic changes of peripheral blood and bone marrow of leukemic mice that received transplants in intermittent hypoxia. FVB/N mice with or without transplantation of leukemic cells (2 × 10⁵) were treated with methods described in Figure 1C. When leukemic mice in normal oxygen were moribund (approximately at day 30), all mice (i, normal mice in normal oxygen; ii, normal mice in hypoxia; iii, leukemic mice in normal oxygen; iv, early-phase leukemic mice in hypoxia; v, middle-phase leukemic mice in hypoxia) were killed. (A) WBCs, RBCs, and PLs in peripheral blood (PB) were counted. Every column represents mean of 3 or 4 mice; error bars represent standard deviation (SD). *P < .001, compared with other groups; #P > .05, compared with mice i and ii. (B) Cytologic analysis by Wright Giemsa staining of peripheral blood (top row) and bone marrow (bottom row). Images were observed under a microscope (original magnification × 100/1.30 numeric aperture [NA] oil objective lens).