Figure 5.
Administration of PS-1145 early after transplantation protects mice from lethal GVHD. Lethally irradiated (1000 cGy) B6 mice underwent transplantation with TCD B10.BR BM alone or with B10.BR spleen cells adjusted to yield a dose of 4 × 106 T cells. Mice that received transplanted TCD BM only were untreated (□, n = 8) or were administered PS-1145 (50 mg/kg, days 0-2) (○, n = 5). Animals that received transplanted TCD BM plus B10.BR T cells were also left untreated (▪, n = 8) or were administered PS-1145 (•, n = 10) on days 0-2. (A) Survival percentages. (B) Weight loss percentages. Data are cumulative results from 2 experiments.
