Compromised innate immunity to viral, not bacterial, infections in PLC-γ2-deficient mice. (A) Four days after intragastric injection of 5 × 10⁸ CFUs L monocytogenes per mouse, bacterial burdens were quantified by colony assay in spleen (circles) and liver (triangles) of alymphoid Rag2^-/-Ilrg^-/- mice (gray symbols, n = 8), Plcg2^-/- mice (open symbols, n = 9), and WT mice (black symbols, n = 9). Data are pooled from 3 independent experiments. ^*WT versus Rag2^-/-Ilrg^-/-P < .001 for spleen and P = .006 for liver; Plcg2^-/- versus Rag2^-/-Ilrg^-/-P = .006 for spleen and P < .001 for liver. (B) Three days after intraperitoneal injection of 5 to 10 × 10³ PFUs MCMV/mouse, virus titers were quantified by plaque assay in spleen (circles) and liver (triangles) of C57BL/6 (dark gray symbols, n = 7), BALB/c (light gray symbols, n = 8) mice, Plcg2^-/- mice (open symbols, n = 7), and WT mice (black symbols, n = 7). Data are pooled from 2 independent experiments. Bars represent the mean value of each group of mice. ^*C57BL/6 versus BALB/c P < .001 for spleen and P < .001 for liver; WT versus BALB/c P < .001 for spleen and P < .001 for liver; and WT versus Plcg2^-/-P < .001 for spleen and P < .001 for liver.