Reduced deformability index of Rac1^–/–;Rac2^–/– erythrocytes. Ektacytometry of Rac1^–/–;Rac2^–/– RBCs was used to determine the maximum value of deformability index (DImax). Results are expressed as mean ± SD of 12 Rac1^–/–;Rac2^–/– blood samples and 6 WT, Rac1^–/–, Rac2^–/– blood samples obtained 2 weeks after completion of treatment with pI-pC. P < .001 by t test for the difference between Rac1^–/–;Rac2^–/– and WT. Rac1^–/– and Rac2^–/– blood samples had no statistically significant difference from WT.