Tandutinib plasma concentration versus time profile for a patient receiving 525 mg twice daily for 28 days. (A) Plasma concentration versus time profile during days 0 to 30. (B) Plasma concentration versus time profile following completion of dosing. Dip in trough concentration on day 13 because of missed dose. Day 27 on the plot corresponds to day 28 of dosing, because for the purposes of the plot the beginning of day 1 is viewed as “time-zero” in units of days. Concentrations on study day 1 and following the day 28 dose result from intense sampling, enabling viewing of the full concentration versus time profile. Other concentrations represent troughs only.