Figure 3.
Figure 3. Kinetics of platelet adhesion on A23187-stimulated mesenteric blood vessels. Mean number (± SEM) of firmly adhering platelets after start of A23187 stimulation of mesenteric endothelium as a function of time upon injection with homologous calcein-labeled platelets in WT (WT) and Tsp1-null mice (Tsp1-/-) in nontreated controls (Control) and in mice treated with irrelevant human IgG (23 mg/kg + 23 mg/kg/h; h-IgG), anti-ADAMTS13 IgG (23 mg/kg + 23 mg/kg/h; p-IgG), and human TSP-1 (80 μg/kg + 80 μg/kg/h); number of mice varied from 1 (h-IgG treatment) to 5 (Tsp1-treated TSP-1-null mice); v indicates number of vessels analyzed; P values were calculated via nonparametric Mann-Whitney test, with 2-tailed P-value (*P < .001 vs Tsp1-/- Control analyzed at minutes 1 and 10, respectively; #P < .05 vs WT Control, analyzed at minute 10).

Kinetics of platelet adhesion on A23187-stimulated mesenteric blood vessels. Mean number (± SEM) of firmly adhering platelets after start of A23187 stimulation of mesenteric endothelium as a function of time upon injection with homologous calcein-labeled platelets in WT (WT) and Tsp1-null mice (Tsp1-/-) in nontreated controls (Control) and in mice treated with irrelevant human IgG (23 mg/kg + 23 mg/kg/h; h-IgG), anti-ADAMTS13 IgG (23 mg/kg + 23 mg/kg/h; p-IgG), and human TSP-1 (80 μg/kg + 80 μg/kg/h); number of mice varied from 1 (h-IgG treatment) to 5 (Tsp1-treated TSP-1-null mice); v indicates number of vessels analyzed; P values were calculated via nonparametric Mann-Whitney test, with 2-tailed P-value (*P < .001 vs Tsp1-/- Control analyzed at minutes 1 and 10, respectively; #P < .05 vs WT Control, analyzed at minute 10).

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