Figure 6.
Photochemically injured intestinal vessel thrombosis. Distribution of occlusion time and mean (horizontal bars) upon injury induction in venules (top panel) and arterioles (bottom panel) of WT and Tsp1-null mice, without (Tsp1-/-) or after pretreatment with human TSP-1 or anti-ADAMTS13 IgGs for the indicated number of mice (m); thin parallel lines reflect the time to first massive thrombus formation in Tsp1-null mice; C indicates nontreated controls; +TSP-1, bolus of 80 μg/kg + infusion of 80 μg/kg/h; and +p-IgG, bolus of anti-ADAMTS13 IgG of 23 mg/kg + infusion of 23 mg/kg/h. P values were calculated via nonparametric Mann-Whitney test with 2-tailed P value.