PFS and OS curves in relation either to combined ZAP-70 and CD38 expression or ZAP-70 and IgV_Hmutational status. (A-B) PFS and OS were significantly longer within the ZAP-70^–CD38^– subgroup (P < .001 and P < .001, respectively). (C-D) Equally, ZAP-70^– M patients experienced both a longer PFS (P < .001) and OS (P < .001). Discordant patients (ZAP-70⁺CD38^–/ZAP-70^–CD38⁺ or ZAP-70⁺ M/ZAP-70^– UM) showed an intermediate outcome.